【學術簡介】 學習經曆: 1993.8-1997.7:南京農業大學,植物保護專業,學士 2004.8-2011.7:南京農業大學,昆蟲毒理與分子生物學專業,博士 教學及研究經曆: 1997.8-2000.8:江蘇省農業科學院-植物保護研究所,助研。 2000.8- 迄今:江蘇省農科院-農産品質量安全與營養研究所,研究員。 2006.7-2007.7:美國國家食品安全與毒理學研究中心(MSU-NFSTC),USDA項目研究。 2007.9-2008.9:中國教育部-加拿大聯合培養博士,加拿大農業食品部-食品研究與發展中心(AAFC-AAC),納米生物膜免疫傳感器(芯片)研究。 2018.5-迄今:聯合國糧農組織(FAO),項目專家,農藥管理(FAO/WHO JMPR、JMPM)
學術社會兼職及榮譽: 加拿大農業食品部-中國教育部聯合培養博士、美國國家食品安全與毒理學研究中心客座研究人員(NFSTC-MSU)、英國皇家化學協會會員(RSC)、聯合國糧農組織(FAO)項目專家、中國食源性微生物檢測技術創新戰略聯盟理事、科技部專家庫成員、國家科技獎勵專家庫成員、江蘇省科技廳/财政廳項目專家庫成員、安徽省普通本科高校食品科學與工程類專業合作委員會專家庫成員、江蘇省333人才、中國植保學會、江蘇省昆蟲學會會員。碩導: 南京農業大學(植物保護)、南昌大學(食品衛生與營養)、beat365在线体育(食品科學)、安徽科技學院(食品與藥品);博導:法國高科(Paristech) 聯合大學; 聯合博士後項目導師: 美國加州大學(Davis)、南非誇祖魯-納塔爾大學。 獲江蘇省科技進步一等獎(2017,排名4)、農業部神農中華農業科技一等獎(2017,排名4)、中國植物保護學會科技進步一等獎(2016,排名4)、江蘇省科技進步二等獎(2014,排名11)、南京市科技進步三等獎(2014,排名1)、蘇州市科技進步三等獎(2016,排名2)、溧陽、常州科技進步一、二等獎(2004,排名4)
【主講課程】 博士研究生: 碩士研究生: 本科生:
【指導碩、博士生研究方向】 博士研究生:食品安全與營養、基于高分辨質譜、代謝組學研究 碩士研究生:食品衛生與營養、食品安全、農産品質量安全、檢測技術、風險分析
【研究領域】 緻力于食品及環境中小分子污染物的風險形成規律、源頭安全生産與過程管控技術研究;緻力于食品安全檢測新技術的研究,包括基于抗體、蛋白、适配體、多肽等方法的研究;已開展農藥、緻病源微生物、毒素、重金屬等基因工程抗體、核酸适配體、多肽的研究。
【主要論著】 1.Sa Dong, Yuan Liu, Xiao Zhang, Chongxin Xu, Xianjin Liu, Cunzheng Zhang*. Development of an immunochromatographic assay for the specific detection of Bacillus thuringiensis (Bt) Cry1Ab toxin. Anal Biochem. 2018 Aug 18. pii: S0003-2697(18)30301-4. DOI: 10.1016/j.ab.2018.08.014 2.Yulou Qiu, Pan Li, Sa Dong, Xiaoshuai Zhang, Qianru Yang, Yulong Wang, Jing Ge, Bruce D. Hammock, Cunzheng Zhang*, Xianjin Liu, Phage-Mediated Competitive Chemiluminescent Immunoassay for Detecting Cry1Ab Toxin by Using an Anti-Idiotypic Camel Nanobody, Journal of Agricultural and Food Chemistry, 2018, 66(4): 950-956 3.Dong, Sa# ; Zhang, Cunzheng#; Liu, Yuan; Zhang, Xiao; Xie, Yajing; Zhong, Jianfeng; Xu, Chongxin; Liu, Xianjin, Simultaneous production of monoclonal antibodies against Bacillus thuringiensis (Bt) Cry1 toxins using a mixture immunization , ANALYTICAL BIOCHEMISTRY, 2017.8.15, 531: 60~66. 4.Beibei Liu; Hang Gong; Yulong Wang; Xiaoshuai Zhang; Pan Li; Yulong Qiu; Liming Wang; Xiude Hua; Yirong Guo; Minghua Wang; Fengquan Liu; Xianjin Liu; Cunzhang Zhang* A gold immunochromatographic assay for simultaneous detection of parathion and triazophos in agricultural products, Analytical Methods, 2017.12.11, 10: 422~428 5.Xu, Chongxin ; Zhang, Cunzheng ; Zhong, Jianfeng; Hu, Hui; Luo, Shimin; Liu, Xiaoqin; Zhang, Xiao; Liu, Yuan; Liu, Xianjin. Construction of an Immunized Rabbit Phage Display Library for Selecting High Activity against Bacillus thuringiensis Cryl F Toxin Single-Chain Antibodies. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017.7.26, 65(29): 6016~6022 6.Chongxin Xu, Xiaoqin Liu, Cunzheng Zhang, Xiao Zhang, Jianfeng Zhong, Yuan Liu, Xiaodan Hu, Manman Lin, Xianjin Liu*. Establishment of a sensitive time-resolved fluoroimmunoassay for detection of Bacillus thuringiensis Cry1Ie toxin based nanobody from a phage display library.Analytical Biochemistry,2017,(518):53-59. 7.Tan Liu, Cunzheng Zhang, Jing Peng, Zhiyong Zhang, Xing Sun, Hui Xiao, Ke Sun, Leiqing Pan, Xianjin Liu, Kang Tu. Residual Behaviors of Six Pesticides in Shiitake from Cultivation to Postharvest Drying Process and Risk Assessment. J. Agric. Food Chem. 2016, 30; 64(47):8977-8985. 8.Sa Dong, Cunzheng Zhang, Xiao Zhang,Yuan Liu, Jianfeng Zhong, Yajing Xie,Chongxin Xu,Ying Ding,Liuquan Zhang,Xianjin Liu*.Production and Characterization of Monoclonal Antibody BroadlyRecognizing Cry1 Toxins by Use of Designed Polypeptide as Hapten[J]. Analytical Chemistry, 2016, (88):7023-7032. 9.Cunzheng Zhang, Li Wang, Zhui Tu, Xing Sun, Qinghua He, Zhaojing Lei, Chongxin Xu,Yuan Liu, Xiao Zhang, Jingyi Yang, Xianjin Liu, Yang Xu. Organophosphorus pesticides Detection using Broad specific Single-Stranded DNA based Fluorescence Polarization Aptamer Assay. Biosensors and Bioelectronics, 55(2014), 216–219. 10.Cun-Zheng Zhang, Zhi-Yong Zhang, Xian-Jin Liu,Wayne Jiang, Yi-Dong Wu. Dissipation and environmental fate of herbicide H-9201 in carrot plantings under field conditions, Food Chemistry, 119 (2010): 874–879. 11.ZHANG Cun-Zheng, YANG Chun-Long, LIU Xian-Jin, CHEN Min, YU Jie. An Indirect Competitive Enzyme-Linked Immunosorbent Assay for Determination of New Herbicide H-9201 in Water. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2011, 39(23), 225–230. 12.ZHANG Cun-zheng, ZHANG Xin-ming, TIAN Zi-hua, He Dan-jun, LIU Xian-jin. Degradation of Chlorpyrifos and Fipronil in Rice from Farm to Fork and Risk Assessment. Agricultural Sciences in China, 2010, 9(5): 754-763. 13.Xiao Zhang,Cunzheng Zhang,Yuan Liu,Xiangyang Yu,Xianjin Liu. Construction of scFv phage display library with hapten-specific repertories and characterization of anti-ivermectin fragment isolated from the library. Eur Food Res Technol, 2010, 231:423-430. 14.Xiao Zhang、Chongxin Xu、Cunzheng Zhang、Yuan Liu、Yajing Xie、Xianjin Liu. Established a new double antibodies sandwich enzyme-linked immunosorbent assay for detecting Bacillus thuringiensis (Bt) Cry1Ab toxin based single-chain variable fragments from a naïve mouse phage displayed library. Toxicon, 2014,81,13-22. 15.Qing-hua He, Yang Xu, Cun-zheng Zhang, Yan-ping Li, Zhi-bing Huang. Phage-borne peptidomimetics as immunochemical reagent in dot-immunoassay for mycotoxin zearalenone. Food Control, Volume 39, May, Pages 56–61. 2014. 16.Li Min, Zhu Min, Zhang Cunzheng, Liu Xianjin, Wan Yakun. Uniform orientation of biotinylated nanobody as an affinity binder for detection of Bacillus thuringiensis (Bt) Cry1Ac toxin. Toxins (Basel). 2014,6(12):3208-22. 17.Xiao Zhang, Yuan Liu, Cunzheng Zhang, Yun Wang, Chongxin Xu, XianjinLiu.. Rapid isolation of single-chain antibodies from a human synthetic phage display library for detection of Bacillus thuringiensis (Bt) Cry1B toxin. Ecotoxicology and Environmental Safety, 2012,81 (1):84–90. 18.Wang, Y; Zhang, X; Zhang, CZ; Liu, Y; Liu, XJ. Isolation of single chain variable fragment (scFv) specific for Cry1C toxin from human single fold scFv libraries. Toxicon,2012; 60 (7): 1290-1297. 19.Pingyan Wang,Guanghui Li, Junrong Yan, Yonghong Hu, Cunzheng Zhang, Xianjin Liu, Yakun Wan. Bactrian camel nanobody-based immunoassay for specific and sensitive detection of Cry1Fa toxin. Toxicon. 2014,15;92:186-92. 20.Wang Li, Liu Xianjin, Zhang Qiang, Zhang Cunzheng, Liu Yuan, Tu Kang ,Tu Jian. Selection of DNA aptamers that bind to four organophosphorus pesticides. Biotechnology Letters,2012,34(5):869-874 21.Chongxin Xu, Xiao Zhang, Xiaoqin Liu, Yuan Liu, Xiaodan Hu, Jianfeng Zhong, Cunzheng Zhang, Xianjin Liu*. Selection and application of broad-specificity human domain antibody for simultaneous detection of Bt Cry toxins [J].Analytical Biochemistry,2016,(512):70-77. 22.Yuan Liu, Aihua Wua, Jing Hu, Manman Lin, Mengtang Wen, Xiao Zhang,Chongxin Xu,Xiaodan Hu,Jianfeng Zhong, Lingxia Jiao,Yajing Xie,Cunzhen Zhang,Xiangyang Yu,Ying Liang,Xianjin Liu. Detection of 3-phenoxybenzoic acid in river water with a colloidal gold-based lateral flow immunoassay [J].Analytical Biochemistry, 2015, 483, 7-11. The other articles will be provided with requirement.
【科研項目】:第一主持人
在研項目: 2016.1-2020.12:國家重點研發計劃(子課題):長江中下遊水稻化肥農藥減施增效技術集成研究與示範--(2016YFD0200803) 2017.6-2020.07:江蘇省農業自主創新項目:基于抗體的小麥生産過程中主要農藥快速殘留檢測技術及産品研發[CX(17)1003] 2015.7-2019.07: 江蘇省農業自主創新項目(子課題):青蝦産業鍊技術創新與集成應用[CX(15)1012] 結題項目(部分): 2015.7-2018.6: 江蘇省農業自主創新項目(子課題):環境污染物對河蟹安全養殖的風險分析[CX(15)1011] 2015.7-2018.6: 江蘇省農業自主創新項目(子課題):斑點叉尾鮰養殖環境污染物本底調查與風險分析[CX(15)1013] 2013.8-2017.12:公益性行業(農業)科研專項(子課題):設施葉類蔬菜産供安全過程管控技術研究與示範 [201303088-15] 2014.9-2017.12:江蘇省科技支撐計劃(社發):基于核酸适體的重金屬汞快速檢測試劑盒\試紙條研發[BE2014722] 2015.1-2016.12:農業部國際交流與合作項目:中國-波蘭(歐盟)農産品安全檢測互信與風險評估聯合實驗室[農業部農财發〔2015〕41号], 2013.8-2015.7:江蘇省農業自主創新重點項目:優質葉菜類蔬菜安全生産、周年供應技術研究[CX(13)3090], 2014.7- 2015.7:江蘇省農業自主創新項目:農産品安全快速檢測試劑盒/試紙條産品熟化與示範應用[CX(14)4080], 2014.7- 2015.7:農業部财政專項-标準制定:驗證霜黴威鹽酸鹽在黃瓜中的殘留限量和霜黴威鹽酸鹽在黃瓜上的殘留試驗
【科研成果及獎勵】 科研獲獎:江蘇省科技進步一等獎(2017,排名4)、農業部神農中華農業科技一等獎(2017,排名4)、中國植物保護學會科技進步一等獎(2016,排名4)、江蘇省科技進步二等獎(2014,排名11)、南京市科技進步三等獎(2014,排名1)、蘇州市科技進步三等獎(2016,排名2)、溧陽、常州科技進步一、二等獎(2004,排名4);
教學獲獎:
【所獲專利】
【在讀碩、博士人數】 4/1
【已畢業碩、博士人數】 5/0
【指導本科生人數】 3
【以上資料更新日期】 2018.09.28
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